The first stage of the Zero Childhood Cancer program began in 2016 with a pilot study for children with high-risk cancer being treated in New South Wales. During this pilot, the platform required to create a personalised medicine pipeline was established and tested. This involved multiple steps, including developing a reception process for cancer samples being sent from all over Australia to a centralised tumour bank, and establishing the best possible methods for molecular profiling, drug screening and drug efficacy testing.
In 2017, following successful completion of the pilot study, a national clinical trial was launched. At 31 October 2018, 127 children with high-risk cancers from all over Australia have been enrolled on the state-of-the-art trial, which will run for three years. The trial is free to all children who meet enrolment criteria and is being sponsored by the Australian and New Zealand Haematology/Oncology group (ANZCHOG).